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Small Drug Uses: Nolvadex (Tamoxifen) is used for treating breast cancer in women.

How Taken: Use Nolvadex as directed by your doctor.

• Nolvadex may be taken by mouth with or without food.
• Take Nolvadex with water or another nonalcoholic liquid.
• Swallow this medication whole. Do not break, crush, or chew before swallowing.
• Continue to take Nolvadex even if you feel well. Do not miss any doses. Taking Nolvadex at the same time each day will help you to remember to take it.

Drug Class and Mechanism: Nolvadex is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

Warnings Precautions: Do not use Nolvadex if:

• you are allergic to any ingredient in Nolvadex;
• you are using Nolvadex to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg;
• you are using Nolvadex to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin);
• you are taking anastrozole.

• Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Nolvadex may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
• Nolvadex may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
• New tumors have occurred in body sites other than the uterus in patients taking Nolvadex . It is unknown if Nolvadex may be the cause. Discuss any questions or concerns with your doctor.
• Women who take Nolvadex to reduce the risk of breast cancer should have a breast exam, mammogram, and gynecological exam before starting and during treatment with Nolvadex.
• Women who may become pregnant should begin taking Nolvadex during a menstrual period. Women who have irregular menstrual periods should have a pregnancy test immediately before starting Nolvadex. Talk to your doctor if you have any questions about how to begin taking Nolvadex.
• Women who may become pregnant must use effective nonhormonal birth control (eg, condoms, diaphragm) during sexual intercourse while they are taking Nolvadex and for 2 months after they stop taking it. Do not use hormonal birth control (eg, birth control pills); it may not work as well while you are taking Nolvadex. Discuss any questions about effective nonhormonal birth control with your doctor.
• Nolvadex will not prevent you from becoming pregnant.
• Lab tests, including breast exams, mammograms, gynecologic exams, complete blood counts, and liver function tests, may be performed while you use Nolvadex . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Nolvadex should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
• Pregnancy and breast-feeding: Nolvadex may cause harm to the fetus. Do not become pregnant while you are using it and for 2 months after you stop using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nolvadex while you are pregnant. It is not known if Nolvadex is found in breast milk. Do not breast-feed while taking Nolvadex.

More Information: Nolvadex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

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